Age-related macular degeneration

P Mitchell, G Liew, B Gopinath, TY Wong - The Lancet, 2018 - thelancet.com
Age-related macular degeneration is a leading cause of visual impairment and severe vision
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …

Inflammation and its role in age-related macular degeneration

A Kauppinen, JJ Paterno, J Blasiak, A Salminen… - Cellular and molecular …, 2016 - Springer
Inflammation is a cellular response to factors that challenge the homeostasis of cells and
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …

Age-related macular degeneration: genetics and biology coming together

LG Fritsche, RN Fariss, D Stambolian… - Annual review of …, 2014 - annualreviews.org
Genetic and genomic studies have enhanced our understanding of complex
neurodegenerative diseases that exert a devastating impact on individuals and society. One …

Retinal pigment epithelium and age‐related macular degeneration: a review of major disease mechanisms

S Somasundaran, IJ Constable… - Clinical & …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a progressive degenerative disease that is the
leading cause of vision loss in the elderly population. Degeneration/dysregulation of the …

Dietary nutrient intake and progression to late age-related macular degeneration in the age-related eye disease studies 1 and 2

E Agrón, J Mares, TE Clemons, A Swaroop, EY Chew… - Ophthalmology, 2021 - Elsevier
Purpose To analyze associations between the dietary intake of multiple nutrients and risk of
progression to late age-related macular degeneration (AMD), its subtypes, and large drusen …

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3

EY Chew, TE Clemons, JP SanGiovanni… - JAMA …, 2014 - jamanetwork.com
Importance The Age-Related Eye Disease Study (AREDS) formulation for the treatment of
age-related macular degeneration (AMD) contains vitamin C, vitamin E, beta carotene, and …

Dietary supplements and disease prevention—a global overview

S Rautiainen, JAE Manson, AH Lichtenstein… - Nature Reviews …, 2016 - nature.com
Dietary supplements are widely used and offer the potential to improve health if
appropriately targeted to those in need. Inadequate nutrition and micronutrient deficiencies …

[HTML][HTML] Neuroprotective strategies for retinal disease

MT Pardue, RS Allen - Progress in retinal and eye research, 2018 - Elsevier
Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …

Role of oxidative stress in retinal disease and the early intervention strategies: a review

J Wang, M Li, Z Geng, S Khattak, X Ji… - … Medicine and Cellular …, 2022 - Wiley Online Library
The retina, owing to its cellular anatomy and physical location, is susceptible to generating
reactive oxygen species (ROS), which are associated with several major retinal diseases …

Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging

AS Prasad - Journal of Trace Elements in Medicine and Biology, 2014 - Elsevier
In the developed countries nearly 30% of the elderly are zinc deficient. Many chronic
diseases seen in the elderly such as atherosclerosis, diabetes, neuro-degenerative …