This review outlines recent insights into ligand recognition, channel gating and ion
permeation for the family of pentameric ligand-gated ion channels (pLGICs). These …

We review a selection of methods for performing enhanced sampling in molecular dynamics
simulations. We consider methods based on collective variable biasing and on tempering …

The precise mechanism by which propofol enhances GABAergic transmission remains
unclear, but much progress has been made regarding the underlying structural and dynamic …

Pentameric ligand-gated ion channels (pLGICs) are ubiquitous neurotransmitter receptors in
Bilateria, with a small number of known prokaryotic homologues. Here we describe a new …

Channels in the outer membrane of Gram-negative bacteria provide essential pathways for
the controlled and unidirectional transport of ions, nutrients and metabolites into the cell. At …

Structural rearrangements underlying functional transitions of pentameric ligand-gated ion
channels (pLGICs) are not fully understood. Using 19 F nuclear magnetic resonance and …

Ion channel modulation by general anesthetics is a vital pharmacological process with
implications for receptor biophysics and drug development. Functional studies have …

While small molecules have been used to induce anesthesia in a clinical setting for well
over a century, a detailed understanding of the molecular mechanism remains elusive. In …

Voltage-gated sodium (NaV) channels are important targets of general anesthetics,
including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic …

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but
molecular mechanisms underlying anesthetic action remain debatable. We found that ELIC …