Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits

T Rafnar, B Gunnarsson, OA Stefansson… - Nature …, 2018 - nature.com
Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-
analysis of two genome-wide association studies of leiomyoma in European women (16,595 …

Implantation and Decidualization in PCOS: Unraveling the Complexities of Pregnancy

S Matsuyama, S Whiteside, SY Li - International Journal of Molecular …, 2024 - mdpi.com
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder in women of
reproductive age, affecting 5–15% globally with a large proportion undiagnosed. This review …

Genetic regulation of transcription in the endometrium in health and disease

S Mortlock, B McKinnon… - Frontiers in Reproductive …, 2022 - frontiersin.org
The endometrium is a complex and dynamic tissue essential for fertility and implicated in
many reproductive disorders. The tissue consists of glandular epithelium and vascularised …

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

N Välimäki, H Kuisma, A Pasanen, O Heikinheimo… - Elife, 2018 - elifesciences.org
Uterine leiomyomas (ULs) are benign tumors that are a major burden to women's health. A
genome-wide association study on 15,453 UL cases and 392,628 controls was performed …

Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

T Garrido-Gomez, N Castillo-Marco… - Elife, 2021 - elifesciences.org
Background: Decidualization of the uterine mucosa drives the maternal adaptation to
invasion by the placenta. Appropriate depth of placental invasion is needed to support a …

Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 …

G Zhao, Y Cao, X Zhu, X Tang, L Ding, H Sun… - Science China Life …, 2017 - Springer
Asherman's syndrome (AS) is a common disease that presents endometrial regeneration
disorder. However, little is known about its molecular features of this aregenerative …

Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal–fetal interface

Y Lou, Z Fu, Y Tian, M Hu, Q Wang, Y Zhou… - Reproductive Biology …, 2023 - Springer
Background Decidual macrophages participate in immune regulation at the maternal–fetal
interface. Abnormal M1/M2 polarization of decidual macrophages might predispose immune …

WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines

MJ Sikora, BM Jacobsen, K Levine, J Chen… - Breast Cancer …, 2016 - Springer
Background Invasive lobular carcinoma (ILC) of the breast typically presents with clinical
biomarkers consistent with a favorable response to endocrine therapies, and over 90% of …

MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism

J Zhou, BK Singh, JP Ho, A Lim, E Bruinstroop… - Autophagy, 2021 - Taylor & Francis
Hepatic macroautophagy/autophagy and fatty acid metabolism are transcriptionally
regulated by nuclear receptors (NRs); however, it is not known whether their transcriptional …

Juxtacrine activity of estrogen receptor α in uterine stromal cells is necessary for estrogen-induced epithelial cell proliferation

W Winuthayanon, SL Lierz, KC Delarosa… - Scientific reports, 2017 - nature.com
Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To
understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed …