From thalidomide to rational molecular glue design for targeted protein degradation
Thalidomide and its derivatives are powerful cancer therapeutics that are among the best-
understood molecular glue degraders (MGDs). These drugs selectively reprogram the E3 …
understood molecular glue degraders (MGDs). These drugs selectively reprogram the E3 …
Relapsed/refractory multiple myeloma: A review of available therapies and clinical scenarios encountered in myeloma relapse
P Bhatt, C Kloock, R Comenzo - Current Oncology, 2023 - mdpi.com
Multiple myeloma remains an incurable disease with the usual disease course requiring
induction therapy, autologous stem cell transplantation for eligible patients, and long-term …
induction therapy, autologous stem cell transplantation for eligible patients, and long-term …
Defining molecular glues with a dual-nanobody cannabidiol sensor
Abstract “Molecular glue”(MG) is a term coined to describe the mechanism of action of the
plant hormone auxin and subsequently used to characterize synthetic small molecule …
plant hormone auxin and subsequently used to characterize synthetic small molecule …
Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis
Eleven novel benzoxazole/benzothiazole‐based thalidomide analogs were designed and
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
synthesized to obtain new effective antitumor immunomodulatory agents. The synthesized …
Target protein localization and its impact on PROTAC-mediated degradation
LM Simpson, L Glennie, A Brewer, JF Zhao… - Cell Chemical …, 2022 - cell.com
Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial
proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal …
proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal …
Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and …
Y Liu, M Li, Y Zheng, C Liu, Y Cao, W Guo, M Liu… - Chemical Engineering …, 2024 - Elsevier
Hydrogel coatings of catheters have attracted extensive attention in the field of medical
devices due to its hydrophilicity and softness, while scarcities of Janus adhesion, adaptive …
devices due to its hydrophilicity and softness, while scarcities of Janus adhesion, adaptive …
Cereblon influences the timing of muscle differentiation in Ciona tadpoles
J Long, A Mariossi, C Cao, Z Mo… - Proceedings of the …, 2023 - National Acad Sciences
Thalidomide has a dark history as a teratogen, but in recent years, its derivates have been
shown to function as potent chemotherapeutic agents. These drugs bind cereblon (CRBN) …
shown to function as potent chemotherapeutic agents. These drugs bind cereblon (CRBN) …
Fragment linker prediction using the deep encoder-decoder network for PROTACs drug design
A drug discovery and development pipeline is a prolonged and complex process that
remains challenging for both computational methods and medicinal chemists and has not …
remains challenging for both computational methods and medicinal chemists and has not …
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
P Song, Z Gao, Y Bao, L Chen, Y Huang, Y Liu… - Journal of Hematology & …, 2024 - Springer
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes,
encompassing development, tissue homeostasis, and cell proliferation. Under normal …
encompassing development, tissue homeostasis, and cell proliferation. Under normal …
The casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon
The Cullin-RING ligase 4 E3 ubiquitin ligase component Cereblon (CRBN) is a well-
established target for a class of small molecules termed immunomodulatory drugs (IMiDs) …
established target for a class of small molecules termed immunomodulatory drugs (IMiDs) …