Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

M Qiu, Y Tang, J Chen, R Muriph… - Proceedings of the …, 2022 - National Acad Sciences
Safe and efficacious systemic delivery of messenger RNA (mRNA) to specific organs and
cells in vivo remains the major challenge in the development of mRNA-based therapeutics …

Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

The effects of protein corona on in vivo fate of nanocarriers

Q Xiao, M Zoulikha, M Qiu, C Teng, C Lin, X Li… - Advanced Drug Delivery …, 2022 - Elsevier
With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

The regulation of nanomaterials and nanomedicines for clinical application: Current and future perspectives

R Foulkes, E Man, J Thind, S Yeung, A Joy… - Biomaterials …, 2020 - pubs.rsc.org
The use of nanomaterials in biomedicine has increased over the past 10 years, with many
different nanoparticle systems being utilised within the clinical setting. With limited emerging …

Active targeting strategies using biological ligands for nanoparticle drug delivery systems

J Yoo, C Park, G Yi, D Lee, H Koo - Cancers, 2019 - mdpi.com
Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as
drug delivery systems. Along with optimization of physicochemical properties, researchers …

Protein corona, understanding the nanoparticle–protein interactions and future perspectives: A critical review

T Kopac - International Journal of Biological Macromolecules, 2021 - Elsevier
Proteins are biopolymers of highly varied structures taking part in almost all processes
occurring in living cells. When nanoparticles (NPs) interact with proteins in biological …

Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Monomicellar assembly to synthesize structured and functional mesoporous carbonaceous nanomaterials

L Peng, H Peng, W Li, D Zhao - Nature Protocols, 2023 - nature.com
The large pores of functional mesoporous carbonaceous nanomaterials have broad
accessibility, making them efficient substrates for the mass transport of chemicals in …