Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

Dose-response relationship between weekly resistance training volume and increases in muscle mass: A systematic review and meta-analysis

BJ Schoenfeld, D Ogborn, JW Krieger - Journal of sports sciences, 2017 - Taylor & Francis
The purpose of this paper was to systematically review the current literature and elucidate
the effects of total weekly resistance training (RT) volume on changes in measures of muscle …

A critical evaluation of the biological construct skeletal muscle hypertrophy: size matters but so does the measurement

CT Haun, CG Vann, BM Roberts, AD Vigotsky… - Frontiers in …, 2019 - frontiersin.org
Skeletal muscle is highly adaptable and has consistently been shown to morphologically
respond to exercise training. Skeletal muscle growth during periods of resistance training …

Muscle atrophy induced by mechanical unloading: mechanisms and potential countermeasures

Y Gao, Y Arfat, H Wang, N Goswami - Frontiers in physiology, 2018 - frontiersin.org
Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

The role of the IGF-1 signaling cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle

RD Barclay, NA Burd, C Tyler, NA Tillin… - Frontiers in …, 2019 - frontiersin.org
Sarcopenia is defined as the combined loss of skeletal muscle strength, function, and/or
mass with aging. This degenerative loss of muscle mass is associated with poor quality of …

Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide‐derived measures of muscle …

MS Brook, DJ Wilkinson, WK Mitchell… - The FASEB …, 2015 - Wiley Online Library
Resistance exercise training (RET) is widely used to increase muscle mass in athletes and
also aged/cachectic populations. However, the time course and metabolic and molecular …

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans

MS Brook, DJ Wilkinson, WK Mitchell… - The Journal of …, 2016 - Wiley Online Library
Key points Resistance exercise training (RET) is one of the most effective strategies for
preventing declines in skeletal muscle mass and strength with age. Hypertrophic responses …

[HTML][HTML] Exploring the impact of obesity on skeletal muscle function in older age

PT Morgan, B Smeuninx, L Breen - Frontiers in Nutrition, 2020 - frontiersin.org
Sarcopenia is of important clinical relevance for loss of independence in older adults. The
prevalence of obesity in combination with sarcopenia ('sarcopenic-obesity') is increasing at …

Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise

MS Brook, DJ Wilkinson, BE Phillips… - Acta …, 2016 - Wiley Online Library
Skeletal muscles comprise a substantial portion of whole body mass and are integral for
locomotion and metabolic health. Increasing age is associated with declines in both muscle …

[HTML][HTML] Role of ingested amino acids and protein in the promotion of resistance exercise–induced muscle protein anabolism

PT Reidy, BB Rasmussen - The Journal of nutrition, 2016 - Elsevier
The goal of this critical review is to comprehensively assess the evidence for the molecular,
physiologic, and phenotypic skeletal muscle responses to resistance exercise (RE) …