[HTML][HTML] Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome
Patients with mutations in the thyroid hormone (TH) cell transporter monocarboxylate
transporter 8 (MCT8) gene develop severe neuropsychomotor retardation known as Allan …
transporter 8 (MCT8) gene develop severe neuropsychomotor retardation known as Allan …
Polar Interactions between Substrate and Flavin Control Iodotyrosine Deiodinase Function
D Lemen, SE Rokita - Biochemistry, 2024 - ACS Publications
Flavin cofactors offer a wide range of chemical mechanisms to support a great diversity in
catalytic function. As a corollary, such diversity necessitates careful control within each …
catalytic function. As a corollary, such diversity necessitates careful control within each …
[HTML][HTML] Development and primary characterization of a human thyroid organoid in vitro model for thyroid metabolism investigation
S Cristiani, A Bertolini, V Carnicelli, L Contu… - Molecular and Cellular …, 2024 - Elsevier
A 3D thyroid model was developed to address the limitations of 2D cultures and study the
effects of compounds like 3-MNT on dehalogenase 1 (IYD) and metabolic activity …
effects of compounds like 3-MNT on dehalogenase 1 (IYD) and metabolic activity …
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
Background Nicotine, the main compound of smoking may exert its effects by changing the
expression of microRNAs (miRNAs). This study was conducted to further investigate the …
expression of microRNAs (miRNAs). This study was conducted to further investigate the …
Hypothyroidism due to biallelic variants in IYD: description of 4 families and a novel variant
E Boros, C Vilain, N Driessens… - European Journal of …, 2024 - academic.oup.com
Biallelic loss-of-function variants in the IYD gene cause hypothyroidism resulting from iodine
wasting. We describe 8 patients (from 4 families in which the parents are first cousins) who …
wasting. We describe 8 patients (from 4 families in which the parents are first cousins) who …
[HTML][HTML] Identification and determination of the urinary metabolite of iodotyrosine in vivo
CX Ji, D Zonias, N Djumaeva, R Cheng, K Salim… - Biochemical and …, 2024 - Elsevier
Background Congenital hypothyroidism screening traditionally relies on detecting elevated
thyroid-stimulating hormone levels, yet this approach may not detect a specific type of …
thyroid-stimulating hormone levels, yet this approach may not detect a specific type of …
Investigation on the role of thyroid hormones and their derivatives in different physiopathogenetic mechanisms using HPLC-MS/MS
A Bertolini - 2024 - usiena-air.unisi.it
Abstract High Performance Liquid Chromatography coupled to Tandem Mass Spectrometry
(HPLC-MS/MS) is a versatile analytical technique widely applied in chemistry, biology …
(HPLC-MS/MS) is a versatile analytical technique widely applied in chemistry, biology …
[引用][C] The growing complexity of the control of the hypothalamic pituitary thyroid axis and brown adipose tissue by leptin
RH Costa-e-Sousa, VL Brooks - 2024 - Elsevier