[HTML][HTML] Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review

EL Stewart, SZ Tan, G Liu, MS Tsao - Translational lung cancer …, 2015 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer related deaths in Canada with non-small cell
lung cancer (NSCLC) being the predominant form of the disease. Tumor characterization …

New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer

GR Oxnard, ME Arcila, J Chmielecki, M Ladanyi… - Clinical cancer …, 2011 - AACR
The management of non–small cell lung carcinoma (NSCLC) has been transformed by the
observation that lung adenocarcinomas harboring mutations in epidermal growth factor …

Clinical Characteristics of Patients With Lung Adenocarcinomas Harboring BRAF Mutations

PK Paik, ME Arcila, M Fara, CS Sima… - Journal of clinical …, 2011 - ascopubs.org
Purpose BRAF mutations occur in non–small-cell lung cancer. Therapies targeting BRAF
mutant tumors have recently been identified. We undertook this study to determine the …

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor–mutant lung adenocarcinomas with acquired resistance to kinase …

MN Balak, Y Gong, GJ Riely, R Somwar, AR Li… - Clinical cancer …, 2006 - AACR
Purpose: In patients whose lung adenocarcinomas harbor epidermal growth factor receptor
(EGFR) tyrosine kinase domain mutations, acquired resistance to the tyrosine kinase …

Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection

YMD Lo, NBY Tsui, RWK Chiu, TK Lau, TN Leung… - Nature medicine, 2007 - nature.com
Current methods for prenatal diagnosis of chromosomal aneuploidies involve the invasive
sampling of fetal materials using procedures such as amniocentesis or chorionic villus …

Sensitive sequencing method for KRAS mutation detection by Pyrosequencing

S Ogino, T Kawasaki, M Brahmandam, L Yan… - The Journal of molecular …, 2005 - Elsevier
Both benign and malignant tumors represent heterogenous tissue containing tumor cells
and non-neoplastic mesenchymal and inflammatory cells. To detect a minority of mutant …

Meta-proteomics for the discovery of protein biomarkers of beef tenderness: An overview of integrated studies

B Picard, M Gagaoua - Food Research International, 2020 - Elsevier
This meta-proteomics review focused on proteins identified as candidate biomarkers of beef
tenderness by comparing extreme groups of tenderness using two-dimensional …

Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses

M Ehrich, AOH Nygren - US Patent 8,476,013, 2013 - Google Patents
Non-invasive prenatal testing is becoming a field of rapidly growing interest. Early detection
of pregnancy-related conditions, including complications during pregnancy and genetic …

Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study

TM Morgan, HM Krumholz, RP Lifton, JA Spertus - Jama, 2007 - jamanetwork.com
ContextGiven the numerous, yet inconsistent, reports of genetic variants being associated
with acute coronary syndromes (ACS), there is a need for comprehensive validation of ACS …

[HTML][HTML] Peptaibiotics: harnessing the potential of microbial secondary metabolites for mitigation of plant pathogens

L Pereira-Dias, PR Oliveira-Pinto, JO Fernandes… - Biotechnology …, 2023 - Elsevier
Agricultural systems are in need of low-cost, safe antibiotics to protect crops from pests and
diseases. Peptaibiotics, a family of linear, membrane-active, amphipathic polypeptides, have …