Glucocorticoid receptor control of transcription: precision and plasticity via allostery
ER Weikum, MT Knuesel, EA Ortlund… - … reviews Molecular cell …, 2017 - nature.com
The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …
factor (TRF) that controls many distinct gene networks, each uniquely determined by …
Epigenetic mechanisms of the glucocorticoid receptor
The glucocorticoid receptor (GR) has been shown to be important for mediating cellular
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …
[HTML][HTML] SIRT6 promotes hepatic beta-oxidation via activation of PPARα
S Naiman, FK Huynh, R Gil, Y Glick, Y Shahar… - Cell reports, 2019 - cell.com
The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression
analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling …
analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling …
Enhancer of rudimentary cooperates with conserved RNA-processing factors to promote meiotic mRNA decay and facultative heterochromatin assembly
Erh1, the fission yeast homolog of Enhancer of rudimentary, is implicated in meiotic mRNA
elimination during vegetative growth, but its function is poorly understood. We show that …
elimination during vegetative growth, but its function is poorly understood. We show that …
Red1 promotes the elimination of meiosis‐specific mRNAs in vegetatively growing fission yeast
T Sugiyama, R Sugioka‐Sugiyama - The EMBO journal, 2011 - embopress.org
Meiosis‐specific mRNAs are transcribed in vegetative fission yeast, and these meiotic
mRNAs are selectively removed from mitotic cells to suppress meiosis. This RNA elimination …
mRNAs are selectively removed from mitotic cells to suppress meiosis. This RNA elimination …
Mapping the dynamics of the glucocorticoid receptor within the nuclear landscape
The distribution of the transcription machinery among different sub-nuclear domains raises
the question on how the architecture of the nucleus modulates the transcriptional response …
the question on how the architecture of the nucleus modulates the transcriptional response …
Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids
Background The glucocorticoid receptor (GR) is a transcription factor that regulates gene
expression in a ligand-dependent fashion. This modular protein is one of the major …
expression in a ligand-dependent fashion. This modular protein is one of the major …
Phase-separation: a possible new layer for transcriptional regulation by glucocorticoid receptor
ES Pinheiro, AM Preato, TVB Petrucci… - Frontiers in …, 2023 - frontiersin.org
Glucocorticoids (GCs) are hormones involved in circadian adaptation and stress response,
and it is also noteworthy that these steroidal molecules present potent anti-inflammatory …
and it is also noteworthy that these steroidal molecules present potent anti-inflammatory …
Mode of glucocorticoid actions in airway disease
K Ito, S Getting, C Charron - The Scientific World Journal, 2006 - Wiley Online Library
Synthetic glucocorticoids are the most potent anti‐inflammatory agents used to treat chronic
inflammatory disease, such as asthma. However, a small number (< 5%) of asthmatic …
inflammatory disease, such as asthma. However, a small number (< 5%) of asthmatic …
The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence
X Deng, Q Yao, A Horvath, Z Jiang, J Zhao… - Nucleic Acids …, 2024 - academic.oup.com
The Cajal body, a nuclear condensate, is crucial for ribonucleoprotein assembly, including
small nuclear RNPs (snRNPs). While Coilin has been identified as an integral component of …
small nuclear RNPs (snRNPs). While Coilin has been identified as an integral component of …