LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy
machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

African swine fever virus (ASFV) is a highly pathogenic swine DNA virus with high mortality
that causes African swine fever (ASF) in domestic pigs and wild boars. For efficient viral …

Type I IFNs (α, β, and others) are a family of cytokines that are produced in physiological
conditions as well as in response to the activation of pattern recognition receptors. They are …

Mitochondria respond to many cellular functions and act as central hubs in innate immunity
against viruses. This response is notably due to their role in the activation of interferon (IFN) …

Autophagy exhibits dual effects during viral infections, promoting the clearance of viral
components and activating the immune system to produce antiviral cytokines. However …

Influenza A virus (IAV) is an infectious pathogen, threatening the population and public
safety with its epidemics. Therefore, it is essential to better understand influenza virus …

Rubicon (Rubcn) was initially identified as a component of the Class III PI 3K complex and a
negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon …

Autophagy is a lysosomal degradation pathway for intracellular components and is highly
conserved across eukaryotes. This process is a key player in innate immunity and its …

The innate immune system is the first line of the host's defense, and studying the
mechanisms of the negative regulation of interferon (IFN) signaling is important for …