Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …