We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …

The field of biomaterials has grown rapidly over the past decades. Within this field, porous
biomaterials have played a remarkable role in:(i) enabling the manufacture of complex three …

Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …

Abstract Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …

Membranes are fundamental elements within organ-on-a-chip (OOC) platforms, as they
provide adherent cells with support, allow nutrients (and other relevant molecules) to …

Advancements in the field of tissue engineering have led to the elucidation of physical and
chemical characteristics of physiological basement membranes (BM) as specialized forms of …

Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the
physiochemical environment of a specific organ in the body. Among various components of …

Biological barriers are multicellular structures that precisely regulate the transport of ions,
biomolecules, drugs, cells, and other organisms. Transendothelial/epithelial electrical …

Microfluidic devices have been used progressively in biomedical research due to the
advantages they offer, such as relatively low-cost, rapid and precise processing, and an …

Drug and chemical development along with safety tests rely on the use of numerous clinical
models. This is a lengthy process where animal testing is used as a standard for pre-clinical …