Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …
Hypoxic pulmonary vasoconstriction
JT Sylvester, LA Shimoda, PI Aaronson… - Physiological …, 2012 - journals.physiology.org
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces
IS Ambudkar, LB de Souza, HL Ong - Cell calcium, 2017 - Elsevier
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …
Calcium signaling in immune cells
M Vig, JP Kinet - Nature immunology, 2009 - nature.com
Calcium acts as a second messenger in many cell types, including lymphocytes. Resting
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …
[HTML][HTML] Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
Summary Stromal interaction molecule-1 (STIM1) activates store-operated Ca 2+ entry
(SOCE) in response to diminished luminal Ca 2+ levels. Here, we present the atomic …
(SOCE) in response to diminished luminal Ca 2+ levels. Here, we present the atomic …
STIMulating store-operated Ca2+ entry
MD Cahalan - Nature cell biology, 2009 - nature.com
Calcium influx through plasma membrane store-operated Ca2+ (SOC) channels is triggered
when the endoplasmic reticulum (ER) Ca2+ store is depleted—a homeostatic Ca2+ …
when the endoplasmic reticulum (ER) Ca2+ store is depleted—a homeostatic Ca2+ …
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
Abstract Stromal interacting molecule 1 (STIM1) is a Ca2+ sensor that conveys the Ca2+
load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma …
load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma …
Activation and regulation of store‐operated calcium entry
JT Smyth, SY Hwang, T Tomita… - Journal of cellular …, 2010 - Wiley Online Library
Introduction• I CRAC• Orais• STIM1• STIM2• STIM1, STIM2 and Ca2+ oscillations• TRPCs
and SOCE• Conclusions The process of store‐operated Ca2+ entry (SOCE), whereby Ca2+ …
and SOCE• Conclusions The process of store‐operated Ca2+ entry (SOCE), whereby Ca2+ …
Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions
KT Cheng, X Liu, HL Ong, W Swaim, IS Ambudkar - PLoS biology, 2011 - journals.plos.org
Store-operated Ca2+ entry (SOCE) has been associated with two types of channels: CRAC
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …