The Pig‐a (phosphatidylinositol glycan, Class A) gene codes for a catalytic subunit of the N‐
acetylglucosamine transferase complex involved in an early step of glycosylphosphatidyl …

Mutations are an inherent risk of cell duplication. On one hand, inheritable mutations are the
driving force of biological evolution; on the other hand, their accumulation in somatic cells …

The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody
binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good …

The ability to effectively monitor gene mutation and micronucleated reticulocyte (MN-RET)
frequency in short-term and repeated dosing schedules was investigated using the recently …

In vivo mutation assays based on the Pig-a null phenotype, that is, the absence of cell
surface glycosylphosphatidylinositol (GPI) anchored proteins such as CD59, have been …

Alternariol (AOH) is one of the toxins of Alternaria, and it has been widely detected in a
variety of foods. It has been reported to be cytotoxic, dermally toxic, genotoxic, and …

Two endpoints of genetic toxicity, mutation at the X-linked Pig-a gene and chromosomal
damage in the form of micronucleated reticulocytes (MN-RETs), were evaluated in blood …

We previously reported the development of an in vivo gene mutation assay using the
phosphatidylinositol glycan complementation group A gene (Pig-A) as an endogenous …

An in vivo mutation assay has been developed based on flow cytometric enumeration of
glycosylphosphatidylinositol (GPI) anchor–deficient rat erythrocytes. With this method, blood …

Base excision repair (BER) is a major pathway for removal of DNA base lesions and
maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases …