ADP-ribosylation from molecular mechanisms to therapeutic implications
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
The discovery of poly (ADP-ribose)> 50 years ago opened a new field, leading the way for
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
the discovery of the poly (ADP-ribose) polymerase (PARP) family of enzymes and the ADP …
Inhibitors of PARP: Number crunching and structure gazing
Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
deficiencies in the repair of DNA via homologous recombination. Here we provide a …
Biology of poly (ADP-ribose) polymerases: the factotums of cell maintenance
P Bai - Molecular cell, 2015 - cell.com
The protein family of poly (ADP-ribose) polymerases (PARPs) or diphtheria toxin-type ADP-
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
S Bilokapic, MJ Suskiewicz, I Ahel, M Halic - Nature, 2020 - nature.com
Breaks in DNA strands recruit the protein PARP1 and its paralogue PARP2 to modify
histones and other substrates through the addition of mono-and poly (ADP-ribose)(PAR) …
histones and other substrates through the addition of mono-and poly (ADP-ribose)(PAR) …
HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity
We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as
a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 …
a regulator of ADP-ribosylation signaling in the DNA damage response. HPF1/C4orf27 …
Identification of poly (ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer
J Rudolph, UM Muthurajan, M Palacio, J Mahadevan… - Molecular cell, 2021 - cell.com
PARP1 is a key player in the response to DNA damage and is the target of clinical inhibitors
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …
Mapping physiological ADP-ribosylation using activated ion electron transfer dissociation
SC Buch-Larsen, IA Hendriks, JM Lodge, M Rykær… - Cell reports, 2020 - cell.com
ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide
range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under …
range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under …
Genome protection by DNA polymerase θ
DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants.
Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by …
Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by …