Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …

Post-translational modifications (PTMs) are important regulators of protein function, and
integrate metabolism with physiological and pathological processes. Phosphorylation and …

Background and Purpose: Sirt5 (Sirtuin 5) desuccinylates multiple metabolic enzymes and
plays an important role in maintaining energy homeostasis. The goal of this study was to …

Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …

Sirtuins (SIRT) are unique posttranslational modification enzymes that utilize NAD+ as co-
substrate to remove acyl groups from lysine residues. SIRT act on variety of substrates and …

Histone deacetylases (HDACs) are enzymes that regulate several processes, such as
transcription, cell proliferation, differentiation and development. HDACs are classified as …

Ethnopharmacological relevance Musk is a representative drug of aroma-relieving
traditional Chinese medicine, and it is a commonly used traditional Chinese medicine for the …

Ischemic accumulation of succinate causes cerebral damage by excess production of
reactive oxygen species. However, it is unknown whether ischemic accumulation of …

Biology | Free Full-Text | Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at
the Interface between Metabolism and Cell Cycle: A Systematic Review Next Article in Journal …

Stroke is a leading cause of mortality and disability worldwide. Ischemic cell death triggered
by the compromised supply of blood oxygen and glucose is one of the major …