Heterogeneity of modulatory immune microenvironment in bladder cancer

E El Saftawy, BE Aboulhoda, MA Alghamdi… - Tissue and Cell, 2024 - Elsevier
Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. The intra-tumor
heterogeneity of the UBC microenvironment explains the variances in response to therapy …

Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk

E Ashouri, K Rajalingam, S Barani, S Farjadian… - Scientific reports, 2021 - nature.com
Human leukocyte antigen (HLA) class I-specific killer-cell immunoglobulin-like receptors
(KIR) regulate natural killer (NK) cell function in eliminating malignancy. Breast cancer (BC) …

Activating and inhibitory killer cell immunoglobulin like receptors (KIR) genes are involved in an increased susceptibility to colorectal adenocarcinoma and protection …

S Barani, SV Hosseini, A Ghaderi - Immunobiology, 2019 - Elsevier
Background: A set of activating and inhibitory KIRs (aKIR, iKIR) are involved in NK cell
mediated immunity. This study was carried out in order to investigate the KIRs pattern and its …

Diversity of KIRs in invasive breast cancer patients and healthy controls along with the clinical significance in ER/PR/HER2+ patients

M Hematian Larki, S Barani, AR Talei, A Ghaderi - Genes & Immunity, 2020 - nature.com
Killer cell immunoglobulin-like receptors (KIR) consists of activating and inhibitory genes are
essential for natural killer cell education. To determine the association of KIR s with …

Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer

Z Shiravani, K Mirshekari, MH Larki, N Shafiee… - Journal of Reproductive …, 2024 - Elsevier
Endometrial cancer (EC) constitutes more than half of all genital cancers in women, with an
increasing incidence in different countries. Natural killer cells (NK cells) are kinds of innate …

Killer cell immunoglobulin‐like receptor (KIR) gene contents: Are they associated with cervical cancer?

AK Tembhurne, A Maheshwari, H Warke… - Journal of Medical …, 2023 - Wiley Online Library
Killer cell immunoglobulin‐like receptors (KIRs) are required for natural killer cell function
against virus‐infected cells or tumor cells. KIR gene content polymorphisms in Indian …

[HTML][HTML] Killer cell immunoglobulin-like receptors (KIRs) genotype and haplotype analysis in Iranians with non-melanoma Skin Cancers

F Yousefinejad, F Jowkar, S Barani… - Iranian Biomedical …, 2019 - ncbi.nlm.nih.gov
Background: The innate immune system against malignancies is mainly orchestrated by
natural killer cells, which carry out killing mechanisms by using their receptors, such as killer …

Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma

S Barani, M Taghipour, A Ghaderi - Immunobiology, 2020 - Elsevier
Background NK cells as a part of innate immune system, are controlled by a set of activating
and inhibitory KIR receptors (aKIR, iKIR) which are implicated in tumor microenvironment …

Understanding the killer-cell immunoglobulin like receptor polymorphism in retinoblastoma

R Aggarwal, M Sharma, U Singh, K Poulton… - Ophthalmic …, 2023 - Taylor & Francis
Background The KIR receptors present on the natural killer (NK) cells play a crucial role by
exercising cytotoxicity to eliminate tumor cells. Both KIR and class-I HLA molecules exhibit …

Expression of Killer Immunoglobulin Receptor Genes among HIV‐Infected Individuals with Non‐AIDS Comorbidities

FF Abou Hassan, M Bou Hamdan… - Journal of …, 2022 - Wiley Online Library
Combined antiretroviral therapy (cART) increased the life expectancy of people living with
HIV (PLHIV) and remarkably reduced the morbidity and mortality associated with HIV …