The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the seventh
known human coronavirus, and it was identified in Wuhan, Hubei province, China, in 2020. It …

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

Background In inflamed tissue, immune cells are accumulated, and various intercellular
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …

Despite the advances in contemporary medicine and availability of numerous innovative
therapies, effective treatment and prevention of SARS-CoV-2 infections pose a challenge. In …

Severe COVID-19 is a systemic disorder involving excessive inflammatory response,
metabolic dysfunction, multi-organ damage, and several clinical features. Here, we …

Abstract On 4 September, 2020, the US National Institutes of Health launched a new clinical
trial,“A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and …

Abstract Microwave-assisted reaction of 3, 5-bis ((E)-ylidene)-1-phosphonate-4-piperidones
3a‒g with azomethine ylide (produced through interaction of isatins 4 and sarcosine 5) …

An overly exuberant immune response, characterized by a cytokine storm and uncontrolled
inflammation, has been identified as a significant driver of severe coronavirus disease 2019 …

Zika virus (ZIKV) is an emerging flavivirus that is causing significant public health concerns
worldwide because of its association with severe neurological disorders in both newborns …

Background: In recent years, the therapeutic options for COVID have significantly improved;
however, the therapies are expensive with restricted access to drugs, and expeditious and …