Background The objective of this article is to summarize the published literature concerning
the pharmacokinetics and pharmacodynamics of oral anticoagulant drugs that are currently …

Currently, there are very few guidelines linking the results of pharmacogenetic tests to
specific therapeutic recommendations. Therefore, the Royal Dutch Association for the …

Objective It is not known whether patients with atrial fibrillation (AF) with ischemic stroke
despite oral anticoagulant therapy are at increased risk for further recurrent strokes or how …

This article concerning the pharmacokinetics and pharmacodynamics of vitamin K
antagonists (VKAs) is part of the American College of Chest Physicians Evidence-Based …

Background Genetic variability among patients plays an important role in determining the
dose of warfarin that should be used when oral anticoagulation is initiated, but practical …

Differences in drug responsiveness are common, often leading to challenges in optimizing
the dosage regimen for a particular patient. Recent advances provide a rational framework …

Background The management of warfarin therapy is complicated by a wide variation among
patients in drug response. Variants in the gene encoding vitamin K epoxide reductase …

Initiation of warfarin therapy using trial‐and‐error dosing is problematic. Our goal was to
develop and validate a pharmacogenetic algorithm. In the derivation cohort of 1,015 …

Current dosing algorithms do not account for genetic and environmental factors for warfarin
dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 …

Pharmacogenetics deals with inherited differences in the response to drugs. The best-
recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which …