A survey of sequence alignment algorithms for next-generation sequencing
Rapidly evolving sequencing technologies produce data on an unparalleled scale. A central
challenge to the analysis of this data is sequence alignment, whereby sequence reads must …
challenge to the analysis of this data is sequence alignment, whereby sequence reads must …
Advanced cell culture techniques for cancer drug discovery
CJ Lovitt, TB Shelper, VM Avery - Biology, 2014 - mdpi.com
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins
D Couvin, A Bernheim, C Toffano-Nioche… - Nucleic acids …, 2018 - academic.oup.com
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their
associated (Cas) proteins confer bacteria and archaea adaptive immunity against …
associated (Cas) proteins confer bacteria and archaea adaptive immunity against …
Construction of a chromosome-scale long-read reference genome assembly for potato
Background Worldwide, the cultivated potato, Solanum tuberosum L., is the No. 1 vegetable
crop and a critical food security crop. The genome sequence of DM1–3 516 R44, a doubled …
crop and a critical food security crop. The genome sequence of DM1–3 516 R44, a doubled …
The Chara genome: secondary complexity and implications for plant terrestrialization
Land plants evolved from charophytic algae, among which Charophyceae possess the most
complex body plans. We present the genome of Chara braunii; comparison of the genome to …
complex body plans. We present the genome of Chara braunii; comparison of the genome to …
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One …
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One …
GMAP and GSNAP for genomic sequence alignment: enhancements to speed, accuracy, and functionality
TD Wu, J Reeder, M Lawrence, G Becker… - … genomics: methods and …, 2016 - Springer
The programs GMAP and GSNAP, for aligning RNA-Seq and DNA-Seq datasets to
genomes, have evolved along with advances in biological methodology to handle longer …
genomes, have evolved along with advances in biological methodology to handle longer …
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
In vivo interrogation of the function of genes implicated in tumorigenesis is limited by the
need to generate and cross germline mutant mice. Here we describe approaches to model …
need to generate and cross germline mutant mice. Here we describe approaches to model …
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
T Tammela, FJ Sanchez-Rivera, NM Cetinbas, K Wu… - Nature, 2017 - nature.com
The heterogeneity of cellular states in cancer has been linked to drug resistance, cancer
progression and the presence of cancer cells with properties of normal tissue stem cells …
progression and the presence of cancer cells with properties of normal tissue stem cells …
[PDF][PDF] Recommendation for the entropy sources used for random bit generation
This Recommendation specifies the design principles and requirements for the entropy
sources used by Random Bit Generators, and the tests for the validation of entropy sources …
sources used by Random Bit Generators, and the tests for the validation of entropy sources …