Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of
publications presenting novel methods for obtaining spatially resolved information for any …

Abstract Information and function of a genome are not only decorated with epigenetic marks
in the linear DNA sequence but also in their non-random spatial organization in the nucleus …

The relationship between the 4D folding of the genome and its function is an outstanding
question in biology. A range of methods that probe the folding of the genome in space and …

The genome of a eukaryotic organism is comprised of a supra-molecular complex of
chromatin fibers and intricately folded three-dimensional (3D) structures. Chromosomal …

Recent advances in genomic and imaging techniques have revealed the complex manner of
organizing billions of base pairs of DNA necessary for maintaining their functionality and …

To identify candidate tissue regeneration enhancer elements (TREEs) important for
zebrafish fin regeneration, we performed ATAC-seq from bulk tissue or purified fibroblasts of …

3D genome folding enables the physical storage of chromosomes into the compact volume
of a cell's nucleus, allows for the accurate segregation of chromatin to daughter cells, and …

Loss-of-function studies have shown that transcription factor T cell factor-1 (TCF1), encoded
by the Tcf7 gene, is essential for T cell development in the thymus. We discovered that the …

Genome-wide association studies (GWASs) have revolutionized human disease genetics by
discovering tens of thousands of associations between common variants and complex …

Background: The concept of “chromosomics” was introduced by Prof. Uwe Claussen in
2005. Herein, the growing insights into human chromosome structure finally lead to a …