Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Asthma affects almost 20 million people in the United States and more than 300 million
people worldwide. Of these, 10-15% have severe asthma, which is refractory to commonly …

Some behavioral researchers occasionally wish to conduct a median split on a continuous
variable and use the result in subsequent modeling to facilitate analytic ease and …

Asthma is the most common chronic lower respiratory disease in childhood throughout the
world. Several guidelines and/or consensus documents are available to support medical …

Background Phenotypic presentations in young children with asthma are varied and might
contribute to differential responses to asthma controller medications. Methods The …

Background Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose
asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for …

The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

BACKGROUND: The goals of asthma treatment include preventing recurrent exacerbations.
Yet there is no consensus about the terminology for describing or defining “exacerbation” or …

Background Anti‐leukotrienes (5‐lipoxygenase inhibitors and leukotriene receptors
antagonists) serve as alternative monotherapy to inhaled corticosteroids (ICS) in the …

Background Exacerbation-associated uncontrolled asthma represents a major public health
problem. The relationship of elevated blood eosinophils to this process needs study …