The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are
critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor …

In the context of OA disease, NF-κB transcription factors can be triggered by a host of stress-
related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM …

The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

Recent genetic evidence has established a pathogenetic role for NF-κB signaling in cancer.
NF-κB signaling is engaged transiently when normal B lymphocytes respond to antigens, but …

The importance of understanding the genetic and biochemical basis of B-cell receptor (BCR)
survival signaling in diffuse large B-cell lymphoma (DLBCL) is underscored by the recent …

Purpose To evaluate the prognostic value of the cell of origin (COO) in patients with
relapsed/refractory diffuse large B-cell lymphoma (DLBLC), prospectively treated by …

Rapid technical advances in DNA sequencing and genome-wide association studies are
driving the discovery of the germline and somatic mutations that are present in different …

MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE)
inhibitor. In most cancer cells tested, inhibition of NAE leads to induction of DNA …