Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …
evolved unique features distinguishing them from all other protein kinases. The atypical …
Prospects for pharmacological targeting of pseudokinases
Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl
transfer, termed pseudokinases, have emerged as important signalling domains across all …
transfer, termed pseudokinases, have emerged as important signalling domains across all …
[HTML][HTML] Ubiquitin ligase COP1 suppresses neuroinflammation by degrading c/EBPβ in microglia
Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation
R Avellino, R Delwel - Blood, The Journal of the American …, 2017 - ashpublications.org
One of the most studied transcription factors in hematopoiesis is the leucine zipper CCAAT-
enhancer binding protein α (C/EBPα), which is mainly involved in cell fate decisions for …
enhancer binding protein α (C/EBPα), which is mainly involved in cell fate decisions for …
Day of the dead: pseudokinases and pseudophosphatases in physiology and disease
Pseudophosphatases and pseudokinases are increasingly viewed as integral elements of
signaling pathways, and there is mounting evidence that they have frequently retained the …
signaling pathways, and there is mounting evidence that they have frequently retained the …
A phyB-PIF1-SPA1 kinase regulatory complex promotes photomorphogenesis in Arabidopsis
Abstract CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a highly conserved E3
ubiquitin ligase from plants to animals and acts as a central repressor of …
ubiquitin ligase from plants to animals and acts as a central repressor of …
A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2 …
Z Liu, K Wu, S Gu, W Wang, S Xie, T Lu… - Clinical and …, 2021 - Wiley Online Library
Background Esophageal squamous cell carcinoma (ESCC) is a highly aggressive and
treatment‐resistant tumor. The biological implications and molecular mechanism of cancer …
treatment‐resistant tumor. The biological implications and molecular mechanism of cancer …
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells
Z Zhang, K Newton, SK Kummerfeld… - Proceedings of the …, 2017 - National Acad Sciences
Alveolar type II (AT2) cell dysfunction contributes to a number of significant human
pathologies including respiratory distress syndrome, lung adenocarcinoma, and debilitating …
pathologies including respiratory distress syndrome, lung adenocarcinoma, and debilitating …
Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase
CCAAT-enhancer binding proteins (C/EBPs) are transcription factors that play a central role
in the differentiation of myeloid cells and adipocytes. Tribbles pseudokinases govern levels …
in the differentiation of myeloid cells and adipocytes. Tribbles pseudokinases govern levels …