Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Chronic inflammation triggers compensatory immunosuppression to stop inflammation and
minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress …

Many tumour cells show dependence on exogenous serine and dietary serine and glycine
starvation can inhibit the growth of these cancers and extend survival in mice. However …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated
anabolic program in response to growth-promoting signals. Paradoxically, recent studies …

ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …

Background Dihydroartemisinin (DHA) has been shown to exert anticancer activity through
iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a …