Disease stratification in GCA and PMR: state of the art and future perspectives
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related conditions
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …
[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …
Metabolic features and glucocorticoid-induced comorbidities in patients with giant cell arteritis and polymyalgia rheumatica in a Dutch and Danish cohort
I Esen, S Arends, BD Nielsen, P Therkildsen… - RMD open, 2023 - rmdopen.bmj.com
Objectives Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are age-associated
inflammatory diseases that frequently overlap. Both diseases require long-term treatment …
inflammatory diseases that frequently overlap. Both diseases require long-term treatment …
Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica
RD Reitsema, BC Hesselink, WH Abdulahad… - Frontiers in …, 2023 - frontiersin.org
Background Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are overlapping
inflammatory diseases. Antigen-presenting cells (APCs), including monocytes and dendritic …
inflammatory diseases. Antigen-presenting cells (APCs), including monocytes and dendritic …
Distinct gene signatures of monocytes and B cells in patients with giant cell arteritis: a longitudinal transcriptome analysis
K Matsumoto, K Suzuki, H Yoshida, M Magi… - Arthritis research & …, 2023 - Springer
Background Giant cell arteritis (GCA) is a primary large-vessel vasculitis (LVV) of unknown
origin. Its management is a challenge due to the late onset of disease symptoms and …
origin. Its management is a challenge due to the late onset of disease symptoms and …
[HTML][HTML] YKL-40 as a biomarker in various inflammatory diseases: A review
YKL-40 or Chitinase-3-Like Protein 1 (CHI3L1) is a highly conserved glycoprotein that binds
heparin and chitin in a non-enzymatic manner. It is a member of the chitinase protein family …
heparin and chitin in a non-enzymatic manner. It is a member of the chitinase protein family …
Altered plasma levels and tissue expression of fibroblast activation protein alpha in giant cell arteritis
Objective Giant cell arteritis (GCA) is characterized by granulomatous inflammation of the
medium‐and large‐sized arteries accompanied by remodeling of the vessel wall. Fibroblast …
medium‐and large‐sized arteries accompanied by remodeling of the vessel wall. Fibroblast …
Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production
E Cantoni, I Merelli, D Stefanoni, A Tomelleri… - …, 2023 - academic.oup.com
Objective Trained immunity (TI) is a de facto memory program of innate immune cells,
characterized by immunometabolic and epigenetic changes sustaining enhanced …
characterized by immunometabolic and epigenetic changes sustaining enhanced …
[PDF][PDF] Tocilizumab in Giant Cell Arteritis: Better Understanding the Benefits
F Buttgereit, A Palmowski, I Esen… - Arthritis and …, 2023 - research.rug.nl
Glucocorticoids have been the treatment mainstay for giant cell arteritis (GCA) for several
decades (1). Current guidelines recommend glucocorticoids as an induction therapy, and …
decades (1). Current guidelines recommend glucocorticoids as an induction therapy, and …
The role of PKM2 in diabetic microangiopathy
C Tu, L Wang, L Wei - … Syndrome and Obesity: Targets and Therapy, 2022 - Taylor & Francis
Diabetic microangiopathy is among the most common complications affecting patients with
diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD) …
diabetes, and includes both diabetic retinopathy (DR) and diabetic nephropathy (DKD) …