Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has
been considered simply a passive Ca2+-buffering protein in the sarcoplasmic reticulum (SR) …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ influx mechanism triggered by
depletion of Ca2+ stores from the endoplasmic/sarcoplasmic reticulum (ER/SR). We recently …

Accumulation of saturated fatty acids contributes to lipotoxicity‐related insulin resistance and
atrophy in skeletal muscle. Conversely, unsaturated fatty acids like docosahexaenoic acid …

Calsequestrin is the major Ca 2+ binding protein in the sarcoplasmic reticulum (SR), serves
as the main Ca 2+ storage and buffering protein and is an important regulator of Ca 2+ …

The purpose of this study was to test mitochondrial functionality under conditions simulating
postmortem metabolism. Isolated mitochondria from porcine longissimus lumborum (LLM) …

Calsequestrin 1 (CASQ1) and Ryanodine receptor 1 (RYR1) are two of the main players in
excitation–contraction (EC) coupling. CASQ1-knockout mice and mice carrying a mutation in …

In humans, hyperthermic episodes can be triggered by halogenated anesthetics [malignant
hyperthermia (MH) susceptibility] and by high temperature [environmental heat stroke (HS)] …

Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic
anhydrases perform a crucial role in the conversion of carbon dioxide and water into …

Central core disease (CCD) is a congenital myopathy linked to mutations in the ryanodine
receptor type 1 (RYR1), the sarcoplasmic reticulum Ca2+ release channel of skeletal …