Radiation effects on development

M De Santis, E Cesari, E Nobili… - … Research Part C …, 2007 - Wiley Online Library
It has been widely reported that prenatal exposure to ionizing radiation can interfere with
embryonic and fetal development, depending on dose and gestational age in which …

Neuronal responses to physiological stress

K Kagias, C Nehammer, R Pocock - Frontiers in genetics, 2012 - frontiersin.org
Physiological stress can be defined as any external or internal condition that challenges the
homeostasis of a cell or an organism. It can be divided into three different aspects …

Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ‐ray radiation

SB Oh, HR Park, YJ Jang, SY Choi… - British journal of …, 2013 - Wiley Online Library
Background and Purpose Whole‐brain irradiation (WBI) therapy produces learning and
memory deficits in patients with brain tumours. Although the pathological cascade of …

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

R Rong, X Xia, H Peng, H Li, M You, Z Liang… - Cell death & …, 2020 - nature.com
Radiation-induced optic neuropathy (RION) is a devastating complication following external
beam radiation therapy (EBRT) that leads to acute vision loss. To date, no efficient, available …

Disease-on-a-chip: mimicry of tumor growth in mammary ducts

PA Vidi, T Maleki, M Ochoa, L Wang, SM Clark… - Lab on a Chip, 2014 - pubs.rsc.org
We present a disease-on-a-chip model in which cancer grows within phenotypically normal
breast luminal epithelium on semicircular acrylic support mimicking portions of mammary …

Genetic regulation of behavioral and neuronal responses to fluoxetine

BH Miller, LE Schultz, A Gulati, MD Cameron… - …, 2008 - nature.com
Despite widespread use of antidepressants, the factors underlying the behavioral response
to antidepressants are unknown. It has been shown that antidepressant treatment promotes …

Neural stem cell apoptosis after low‐methylmercury exposures in postnatal hippocampus produce persistent cell loss and adolescent memory deficits

K Sokolowski, M Obiorah, K Robinson… - Developmental …, 2013 - Wiley Online Library
The developing brain is particularly sensitive to exposures to environmental contaminants.
In contrast to the adult, the developing brain contains large numbers of dividing neuronal …

Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures

K Sokolowski, A Falluel-Morel, X Zhou… - Neurotoxicology, 2011 - Elsevier
The developing brain is particularly sensitive to environmental teratogens, such as
methylmercury (MeHg), which may induce cell death. Although several mechanisms of …

Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice

NMB Ben Abdallah, L Slomianka, HP Lipp - Hippocampus, 2007 - Wiley Online Library
Therapeutic cranial X‐irradiation causes cognitive deficits in adult and pediatric patients, in
particular, when the exposed area includes the medial temporal lobes. Effects on adult …

Comparable Attenuation of Aβ25–35-Induced Neurotoxicity by Quercitrin and 17β-Estradiol in Cultured Rat Hippocampal Neurons

S Rattanajarasroj, S Unchern - Neurochemical research, 2010 - Springer
In the present work, potential protective effects of quercitrin (a phytoestrogen) on Aβ-induced
neurotoxicity in cultured rat hippocampal neurons were investigated in comparison with 17β …