The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Spermidine in health and disease

F Madeo, T Eisenberg, F Pietrocola, G Kroemer - Science, 2018 - science.org
BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity

F Magkos, G Fraterrigo, J Yoshino, C Luecking… - Cell metabolism, 2016 - cell.com
Summary Although 5%–10% weight loss is routinely recommended for people with obesity,
the precise effects of 5% and further weight loss on metabolic health are unclear. We …

Antioxidant effects of resveratrol in the cardiovascular system

N Xia, A Daiber, U Förstermann… - British journal of …, 2017 - Wiley Online Library
The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …

Biological activities of stilbenoids

BC Akinwumi, KAM Bordun, HD Anderson - International journal of …, 2018 - mdpi.com
Stilbenoids are a group of naturally occurring phenolic compounds found in various plant
species. They share a common backbone structure known as stilbene, but differ in the …

Mechanisms of aging and the preventive effects of resveratrol on age-related diseases

IS Pyo, S Yun, YE Yoon, JW Choi, SJ Lee - Molecules, 2020 - mdpi.com
Aging gradually decreases cellular biological functions and increases the risk of age-related
diseases. Cancer, type 2 diabetes mellitus, cardiovascular disease, and neurological …

Effect of resveratrol and pterostilbene on aging and longevity

YR Li, S Li, CC Lin - Biofactors, 2018 - Wiley Online Library
Over the past years, several studies have found that foods rich in polyphenols protect
against age‐related disease, such as atherosclerosis, cardiovascular disease, cancer …

Resveratrol, metabolic syndrome, and gut microbiota

A Chaplin, C Carpéné, J Mercader - Nutrients, 2018 - mdpi.com
Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic
syndrome-related alterations in experimental animals, including glucose and lipid …

A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health

MJ Banez, MI Geluz, A Chandra, T Hamdan… - Nutrition Research, 2020 - Elsevier
The potential benefits of supplemental nutrients and dietary interventions against
cardiovascular morbidity and mortality have been extensively investigated throughout the …