Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Manganese is an essential trace metal. The dysregulation of manganese seen in a broad
spectrum of neurological disorders reflects its importance in brain development and key …

Abstract Purpose of Review This article provides an overview of the pathogenesis, clinical
presentation and treatment of inherited manganese transporter defects. Recent Findings …

Abstract In 2016, the Movement Disorder Society Task Force for the Nomenclature of
Genetic Movement Disorders presented a new system for naming genetically determined …

Iron is an essential transition metal for its involvement in several crucial biological functions,
the most notable being oxygen storage and transport. Due to its high reactivity and potential …

As an essential nutrient, manganese is required for the regulation of numerous cellular
processes, including cell growth, neuronal health, immune cell function, and antioxidant …

ZIP14 (encoded by the solute carrier 39 family member 14 (SLC39A14) gene) is a
manganese transporter that is abundantly expressed in the liver and small intestine. Loss-of …

Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse
cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is …

Congenital disorders of manganese metabolism are rare occurrences in children, and
medical management of these disorders is complex and challenging. Homozygous exonic …

Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific
brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is …