Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production

MZ Abdin, M Israr, RU Rehman, SK Jain - Planta medica, 2003 - thieme-connect.com
Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge, has been isolated
from the aerial parts of Artemisia annua L. plants. It is effective against both drug-resistant …

A review of biotechnological artemisinin production in plants

NKBK Ikram, HT Simonsen - Frontiers in Plant Science, 2017 - frontiersin.org
Malaria is still an eminent threat to major parts of the world population mainly in sub-
Saharan Africa. Researchers around the world continuously seek novel solutions to either …

[图书][B] Functions of plant secondary metabolites and their exploitation in biotechnology

M Wink - 1999 - books.google.com
Annual Plant Reviews, Volume 3 The structure of this volume is slanted towards plant
protection, with authors offering new insights into the functions of plant secondary …

Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

W Banyai, C Kirdmanee, M Mii… - Plant Cell, Tissue and …, 2010 - Springer
Transgenic plants of Artemisia annua L., a medicinal plant that produces the compound
artemisinin which has an anti-malarial activity, were developed following Agrobacterium …

Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L.

JM Al-Khayri, WN Sudheer, VV Lakshmaiah… - Molecules, 2022 - mdpi.com
Artemisinin is an anti-malarial sesquiterpene lactone derived from Artemisia annua
L.(Asteraceae family). One of the most widely used modes of treatment for malaria is an …

Influence of different strains of Agrobacterium rhizogenes on induction of hairy roots and artemisinin production in Artemisia annua

A Giri, ST Ravindra, V Dhingra, ML Narasu - Current science, 2001 - JSTOR
Different strains of Agrobacterium rhizogenes, viz. A4, 15834, K599, LBA 9402, 9365 and
9340, were evaluated for induction of transformed hairy roots in Artemisia annua using shoot …

Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation

E Dilshad, RM Cusido, KR Estrada, M Bonfill, B Mirza - PLoS One, 2015 - journals.plos.org
The potent antimalarial drug artemisinin has a high cost, since its only viable source to date
is Artemisia annua (0.01–0.8% DW). There is therefore an urgent need to design new …

An updated review on distribution, biosynthesis and pharmacological effects of artemisinin: A wonder drug

N Nabi, S Singh, P Saffeullah - Phytochemistry, 2023 - Elsevier
Plant-based drugs have been used for centuries for treating different ailments. Malaria, one
of the prevalent threats in many parts of the world, is treated mainly by artemisinin-based …

High efficiency of genetic transformation and regeneration of Artemisia annua L. via Agrobacterium tumefaciens-mediated procedure

J Han, H Wang, H Ye, Y Liu, Z Li, Y Zhang, Y Zhang… - Plant Science, 2005 - Elsevier
Artemisinin is a new effective antimalarial drug extracted from the medicinal plant Artemisia
annua L. There is a great interest in enhancing the production of artemisinin by means of …

Enhanced artemisinin yield by expression of rol genes in Artemisia annua

E Dilshad, RM Cusido, J Palazon, KR Estrada… - Malaria journal, 2015 - Springer
Background Despite of many advances in the treatment of malaria, it is still the fifth most
prevalent disease worldwide and is one of the major causes of death in the developing …