Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

The treatment of schizophrenia has evolved over the past half century primarily in the
context of antipsychotic drug development. Although there has been significant progress …

The members of the chromogranin–secretogranin family of peptide hormones, biogenic
amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system …

Abstract Background Neuroendocrine tumors (NETs) are a form of cancer that differ from
other neoplasia in that they synthesize, store, and secrete peptides, eg, chromogranin A …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Phenotypic modification of dorsal root ganglion (DRG) neurons represents an important
mechanism underlying neuropathic pain. However, the nerve injury-induced molecular …

It is becoming increasingly apparent that beta cell dysfunction resulting in abnormal insulin
secretion is the essential element in the progression of patients from a state of impaired …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

The secretory prohormone chromogranin A (CHGA) is overexpressed in essential
hypertension, a complex trait with genetic predisposition, while its catecholamine release …