Signal transducers and activators of transcription (STATs) mediate essential signaling
pathways in different biological processes, including immune responses, hematopoiesis …

The primary cause of cancer-related death from solid tumors is metastasis. While unraveling
the mechanisms of this complicated process continues, our ability to effectively target and …

Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we
probed estrogen receptor-α (ER) and progesterone receptor (PR) cross-talk in breast cancer …

The growth of advanced prostate cancer depends on androgen receptor signalling, however
treatment options are limited. Here we report the disruption of specific protein–protein …

Tumor metastasis is the leading cause of death among breast cancer patients. PELP1
(proline, glutamic acid and leucine rich protein 1) is a nuclear receptor coregulator that is …

Most patients with estrogen receptor alpha–positive (ER+) breast cancers initially respond to
treatment but eventually develop therapy resistance with disease progression …

Introduction The estrogen receptor (ER) co-regulator proline glutamic acid and leucine-rich
protein 1 (PELP1) is a proto-oncogene that modulates epigenetic changes on ER target …

Estrogen receptor alpha (ERα) is implicated in the initiation and progression of breast
cancer and its transcription depends on the modulation of epigenetic changes at target gene …

The ability of 17β-estradiol (E2) to regulate the proliferation of prostate cancer (PCa) cells in
the absence of androgen is poorly understood. Here, we show the predominant estrogen …

A significant proportion of estrogen receptor‐positive (ER+) breast cancer (BC) initially
responds to endocrine therapy but eventually evolves into therapy‐resistant BC …