The pathological mechanisms of estrogen-induced cholestasis: current perspectives

Y Zu, J Yang, C Zhang, D Liu - Frontiers in Pharmacology, 2021 - frontiersin.org
Estrogens are steroid hormones with a wide range of biological activities. The excess of
estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently …

[HTML][HTML] Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes and preeclampsia

C Liu, J Gao, J Liu, X Wang, J He, J Sun… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Previous studies have shown that intrahepatic cholestasis of pregnancy (ICP) is
associated with an increased incidence of adverse perinatal outcomes, and this supports the …

Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study

K Wu, B Yin, S Li, X Zhu, B Zhu - Annals of Medicine, 2022 - Taylor & Francis
Background Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-
related liver disorder and may cause adverse perinatal outcomes. This large cross-sectional …

The impact of intrahepatic cholestasis on pregnancy outcomes: a retrospective cohort study

Y Chen, H Zhang, W Ning, Y Chen, C Wen - BMC gastroenterology, 2023 - Springer
Background This study analyzed the pregnancy outcomes of patients with intrahepatic
cholestasis of pregnancy (ICP) in Hangzhou, China. Methods Cases of pregnant women …

Association of elevated maternal serum total bile acids with low birth weight and intrauterine fetal growth restriction

F Song, Y Chen, L Chen, H Li, X Cheng… - JAMA network …, 2021 - jamanetwork.com
Importance Bile acids play essential roles in metabolic modulation. Excessive serum total
bile acid (sTBA) levels during pregnancy are associated with adverse perinatal outcomes; …

Intrahepatic cholestasis of pregnancy: from an obstetrician point of view

MMA Abdelhafez, KAM Ahmed, WW Than… - Journal of Obstetrics …, 2022 - Taylor & Francis
Intrahepatic cholestasis of pregnancy (ICP) is the commonest among the specific
dermatoses of pregnancy. The disease is characterised by intense pruritus and specifically …

Guideline No. 452: diagnosis and management of intrahepatic cholestasis of pregnancy

SR Hobson, ER Cohen, S Gandhi, V Jain… - Journal of Obstetrics and …, 2024 - Elsevier
Objective To summarize the current evidence and to make recommendations for the
diagnosis and management of intrahepatic cholestasis of pregnancy. Target Population …

The association of serum total bile acid with new-onset hypertension during pregnancy

W Deng, L Zhang, Q Du, Y Li, J Chen, L Du… - BMC Pregnancy and …, 2022 - Springer
Background There has been considerable interest in the interrelationship between the liver
and hypertension. The relationship between serum total bile acid (TBA) and hypertension …

Intrahepatic cholestasis of pregnancy and associated adverse maternal and fetal outcomes: a retrospective case‐control study

M Luo, M Tang, F Jiang, Y Jia, RKH Chin… - Gastroenterology …, 2021 - Wiley Online Library
Objective. Intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy‐related liver
disease and is associated with an increased risk of adverse neonatal outcomes …

Metabolic changes in bile acids with pregnancy progression and their correlation with perinatal complications in intrahepatic cholestasis of pregnant patients

Z Ma, Y Liu, L Chai, G Jin, Y Sun, S Zhou, P Yin… - Scientific Reports, 2023 - nature.com
Intrahepatic cholestasis of pregnancy (ICP) is a rare liver disease occurring during
pregnancy that is characterized by disordered bile acid (BA) metabolism. It is related to …