Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Endothelial cells play an obligatory role in regulating local vascular tone and maintaining
homeostasis in vascular biology. Cell metabolism, converting food to energy in organisms, is …

Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal cells
lining the sinusoidal capillaries of the hepatic system. LSECs are characterized with …

LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

Liver sinusoidal endothelial cells (LSECs) are the gatekeeper cells in the liver, contributing
critical roles in liver physiological and pathological changes. Factors such as dietary …

Chronic liver injury can be caused by many factors, including virus infection, alcohol intake,
cholestasis and abnormal fat accumulation. Nonalcoholic steatohepatitis (NASH) has …

Aging leads to systemic metabolic disorders, including steatosis. Here we show that liver
sinusoidal endothelial cell (LSEC) senescence accelerates liver sinusoid capillarization and …

Neutrophils are the most abundant type of leukocytes with diverse functions in immune
defense including production of reactive oxygen species, bacteriocidal proteins, neutrophil …

Background Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called
fenestrations, participating in the bidirectional transport between the vascular system and …