Alternative splicing, epigenetic modifications and cancer: a dangerous triangle, or a hopeful one?

F Gimeno-Valiente, G López-Rodas, J Castillo… - Cancers, 2022 - mdpi.com
Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

N6-Methyladenosine-modified lncRNA LINREP promotes Glioblastoma progression by recruiting the PTBP1/HuR complex

X Ji, Z Liu, J Gao, X Bing, D He, W Liu… - Cell Death & …, 2023 - nature.com
Glioblastoma multiforme (GBM) is acknowledged as the most aggressive primary brain
tumor in adults. It is typically characterized by the high heterogeneity which corresponds to …

UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells

S Zhou, J Dong, M Xiong, S Gan, Y Wen, J Zhang… - Stem cell reports, 2022 - cell.com
Life-long male fertility relies on exquisite homeostasis and the development of
spermatogonial stem cells (SSCs); however, the underlying molecular genetic and …

[HTML][HTML] UHRF1/DNMT1–MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in …

S Lin, H Xu, L Qin, M Pang, Z Wang, M Gu… - … Pharmaceutica Sinica B, 2023 - Elsevier
As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG
methylation-mediated disruption of alternative splicing is increasingly recognized as a driver …

Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3‐Regulated Histone Deacetylation and Transcription

CH Li, SB Liang, QW Huang, ZZ Zhou, Z Ding… - Advanced …, 2024 - Wiley Online Library
RNA splicing is crucial in the multilayer regulatory networks for gene expression, making
functional interactions with DNA‐and other RNA‐processing machineries in the nucleus …