Molecular mechanisms of thyroid hormone effects on bone growth and function

CB Harvey, PJ O'Shea, AJ Scott, H Robson… - Molecular genetics and …, 2002 - Elsevier
Linear growth and skeletal maturation occur during fetal and childhood development and
continue until epiphyseal fusion occurs. This process results from endochondral ossification …

Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney

C Schmutzler, I Hamann, PJ Hofmann, G Kovacs… - Toxicology, 2004 - Elsevier
To assess interference with endocrine regulation of the thyroid axis, rats (female,
ovariectomised) were treated for 12 weeks with the suspected endocrine active compounds …

17β-Estradiol and anti-estrogen ICI: compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal …

SL Palin, PG McTernan, LA Anderson, DW Sturdee… - Metabolism, 2003 - Elsevier
We sought to investigate the influence of 17 [beta]-estradiol (E2) on key enzymes of
lipogenesis and lipolysis in subcutaneous (SC) abdominal adipocytes isolated from women …

Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary

A Elango, B Shepherd, TT Chen - General and comparative endocrinology, 2006 - Elsevier
It is now widely accepted that chemical pollutants in the environment can interfere with the
endocrine system of animals, thus affecting development and reproduction. Some of these …

The effect of thyroidectomy and propylthiouracil-induced hypothyroidism on insulin secretion in male rats

A Godini, A Ghasemi, N Karbalaei… - Hormone and …, 2014 - thieme-connect.com
Data available on thyroid dysfunction and insulin secretion are inconsistent. The aim of this
study was to assess the effect of hypothyroidism on insulin secretion, in vivo and in vitro, in …

Identification of new triarylethylene oxyalkanoic acid analogues as bone selective estrogen mimetics

VN Rubin, PC Ruenitz, FD Boudinot, JL Boyd - Bioorganic & medicinal …, 2001 - Elsevier
Previously, the estrogen receptor (ER) ligand 4-[1-(p-hydroxyphenyl)-2-phenylethyl]
phenoxyacetic acid (5) was found to have differential bone loss suppressive effects in the …

Estrogen and Tamoxifen Interplay with T3 in Male Rats: Pharmacologically Distinct Classes of Estrogen Responses Affecting Growth, Bone, and Lipid Metabolism …

JM Fitts, RM Klein, CA Powers - Endocrinology, 2001 - academic.oup.com
Estrogen (E) and T3 regulate gene expression by receptor mechanisms that may enable
hormonal interplay affecting growth and metabolism. Prior studies of E and tamoxifen (TM) …

Agonistic activity of ICI 182 780 on activation of GSK 3β/AKT pathway in the rat uterus during the estrous cycle

N Baranda-Avila, CA Mendoza-Rodríguez, S Morimoto… - Steroids, 2013 - Elsevier
We examined the ability of ICI 182,780 (ICI) to block uterine cell proliferation via protein
kinase b/AKT pathway in the uterus of the rat during the estrous cycle. Intact rats, with …

Initial induction and subsequent reduction of α2u-globulin in urine and serum of mature male rats after repeated intraperitoneal injections of (anti) estrogen

H Nagahori, K Komai, Y Tomigahara, K Saito, N Isobe… - Toxicology, 2001 - Elsevier
The influence of sex (anti) hormones on expression of α2u-globulin (a2uG) is complex and
has not been sufficiently detailed. In order to assess the specificity of sex (anti) hormone …

[引用][C] Tamoxifen regulation of bone growth and endocrine function in the ovariectomized rat: discrimination of responses involving estrogen receptor α/estrogen …

JM Fitts, RM Klein, CA Powers - Journal of Pharmacology and Experimental …, 2011 - ASPET