Proline metabolism features prominently in the unique metabolism of cancer cells. Proline
biosynthetic genes are consistently upregulated in multiple cancers, while the proline …

Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation,
brain development, and other cellular and physiological processes. Here, we focus our …

African swine fever virus (ASFV), as a member of the large DNA viruses, may regulate
autophagy and apoptosis by inhibiting programmed cell death. However, the function of …

Inborn errors of metabolism cause a wide spectrum of neurodevelopmental and
neurodegenerative conditions [15]. A pivotal enzyme located at the intersection of the amino …

Serine hydroxymethyltransferase (SHMT) is one of the most important enzyme families in
one-carbon metabolic pathway and photorespiration within plant cells. Recently studies …

The mitochondrial serine protease HTRA2 has many versatile biological functions ranging
from being an important regulator of apoptosis to being an essential component for neuronal …

Hypomyelinating leukodystrophies (HLDs) represent a group of congenital rare diseases for
which the responsible genes have been identified in recent studies. In this review, we briefly …

Abstract Pyrroline-5-carboxylate reductase (PYCR in humans) catalyzes the final step of l-
proline biosynthesis by catalyzing the reduction of L-Δ 1-pyrroline-5-carboxylate (L-P5C) to l …

The final step in proline biosynthesis is catalyzed by three pyrroline-5-carboxylate
reductases, PYCR1, PYCR2, and PYCR3, which convert pyrroline-5-carboxylate (P5C) to …

Hypomyelinating leukodystrophy 10 (HLD10) is an autosomal recessive disease related to
myelin sheaths in the central nervous system (CNS). In the CNS, myelin sheaths are derived …