DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids,
DAG and phosphatidic acid (PA), by phosphorylating DAG to yield PA. To date, ten …

Anergic T cells have altered diacylglycerol metabolism, but whether that altered metabolism
has a causative function in the induction of T cell anergy is not apparent. To test the …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

The ability of vitamin E to modulate signal transduction and gene expression has been
observed in numerous studies; however, the detailed molecular mechanisms involved are …

The mammalian diacylglycerol kinases (DGK) are a group of enzymes having important
roles in regulating many biological processes. Both the product and the substrate of these …

The protein known as mammalian target of rapamycin (mTOR) regulates cell growth by
integrating different stimuli, such as available nutrients and mitogenic factors. The lipid …

Diacylglycerol is an essential second messenger in mammalian cells. The most prominent
intracellular targets of diacylglycerol and the functionally analogous phorbol esters belong to …

Simple Summary Diacylglycerol (DG) kinase (DGK) phosphorylates DG to generate
phosphatidic acid (PA). DGKα is highly expressed in several refractory cancer cells …

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In
most cases, members of this large family of enzymes appear to bind and regulate proteins …