Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

E Trenkenschuh, W Friess - European journal of pharmaceutics and …, 2021 - Elsevier
Lyophilization of nanoparticle (NP) suspensions is a promising technology to improve
stability, especially during long-term storage, and offers new routes of administration in solid …

Freeze-drying: A flourishing strategy to fabricate stable pharmaceutical and biological products

KK Abla, MM Mehanna - International journal of pharmaceutics, 2022 - Elsevier
Freeze-drying (FD) of nanoparticles, microorganisms, genes, and vaccines is an auspicious
technique used to enhance long-term stability and facilitate transportation mainly for …

Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and freeze drying techniques

Y Guo, A Baldelli, A Singh, F Fathordoobady, D Kitts… - Scientific reports, 2022 - nature.com
Insulin nanoparticles (NPs) with high loading content have found diverse applications in
different dosage forms. This work aimed to evaluate the impact of freeze-drying and spray …

Potential applications of dairy whey for the production of lactic acid bacteria cultures

GR Rama, D Kuhn, S Beux, MJ Maciel… - International Dairy …, 2019 - Elsevier
Lactic acid bacteria (LAB) are applied in the food industry as fermentation agents for a
variety of products. Cheese whey (CW) and second cheese whey (SCW) are the two main …

Preparation of highly stable oleogel-based nanoemulsions for encapsulation and controlled release of curcumin

CA Palla, A Aguilera-Garrido, ME Carrín… - Food Chemistry, 2022 - Elsevier
Oleogels have been proposed as suitable systems for the encapsulation and delivery of
lipophilic bioactive compounds. This work aimed to produce stable nanoemulsions of gelled …

Science and art of protein formulation development

W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules

M Gao, X Long, J Du, M Teng, W Zhang, Y Wang… - Food & Function, 2020 - pubs.rsc.org
Infections caused by bacteria represent an emerging public health threat due to the
development of antibiotic resistance in bacteria. Curcumin (CUR), a naturally derived …

Brij-stabilized zein nanoparticles as potential drug carriers

A Gagliardi, S Voci, MC Salvatici, M Fresta… - Colloids and Surfaces B …, 2021 - Elsevier
The current study was designed to provide a preliminary physico-chemical characterization
of zein nanosystems prepared with various Brij surfactants (for the first time to the best of our …

Polyelectrolyte nanoparticles based on poly [N-(2-hydroxypropyl) methacrylamide-block-poly (N-(3-aminopropyl) methacrylamide] copolymers for delivery of heparin …

GS García-Briones, R Laga, Z Černochová… - European Polymer …, 2023 - Elsevier
In addition to the delivery of therapeutic nucleic acids and low-molecular weight drugs,
polyelectrolyte nanoparticles (NPs) have recently been studied as carriers for protein …

Oral delivery of gambogenic acid by functional polydopamine nanoparticles for targeted tumor therapy

B Wang, T Yuan, L Zha, Y Liu, W Chen… - Molecular …, 2021 - ACS Publications
To enhance the water solubility, oral bioavailability, and tumor targeting of gambogenic acid
(GNA), polydopamine nanoparticles (PDA NPs) were prepared to encapsulate and stabilize …