The characteristic epigenetic profile of periodontitis found in peripheral leukocytes denotes
its impact on systemic immunity. In fact, this profile not only stands for periodontitis as a low …

Type 2 diabetes (T2D) is a common chronic disease whose etiology is known to have a
strong genetic component. Standard genetic approaches, although allowing for the …

Introduction Apical periodontitis (AP) is a common oral disease caused by the inflammatory
destruction of the periapical tissues due to the infection of the root canal system of the tooth …

Thrombospondin-1 (TSP1) is the prototypical member of a family of secreted proteins that
modulate cell behavior by engaging with molecules in the extracellular matrix and with …

CD47, also known as integrin-associated protein, is a constitutively and ubiquitously
expressed transmembrane receptor. CD47 is conserved across amniotes including …

Background Type 2 diabetes mellitus (DM) is a complex metabolic disorder that causes
various complications, including periodontitis (PD). Although a bidirectional relationship has …

Alzheimer's disease (AD) and type 2 diabetes (T2D) are common in the general elderly
population, conferring heavy individual, social, and economic stresses on families and …

Abstract Background Although Vanins are closely related to neutrophil regulation and
response to oxidative stress, and play essential roles in inflammatory diseases with clinical …

Background Patients with major depressive disorder (MDD) face an elevated risk of type 2
diabetes (T2D). However, the contribution of the disease itself versus the side effects of …

Periodontitis and related systemic inflammatory diseases are characterized by imbalanced
ratio between pro-and anti-inflammatory factors. Probiotics may control inflammation by …