Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Anti-diabetic drugs recent approaches and advancements
J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
A series of thirty (30) thiazole analogs were prepared, characterized by 1 H NMR, 13 C NMR
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …
Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies
Thirty derivatives of flavone hydrazone (5–34) had been synthesized through a five-step
reaction and screened for their α-glucosidase inhibition activity. Chalcone 1 was …
reaction and screened for their α-glucosidase inhibition activity. Chalcone 1 was …
Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
We have synthesized seventeen Coumarin based derivatives (1–17), characterized by 1
HNMR, 13 CNMR and EI-MS and evaluated for α-glucosidase inhibitory potential. Among …
HNMR, 13 CNMR and EI-MS and evaluated for α-glucosidase inhibitory potential. Among …
Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
Abstract α-Amylase is a target for type-2 diabetes mellitus treatment. However, small
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
A review exploring therapeutic worth of 1, 3, 4-oxadiazole tailored compounds
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies
Schiff base derivatives were synthesized in this study via conventional, microwave
irradiation and ultrasound sonication methods. Optimization conditions were examined for …
irradiation and ultrasound sonication methods. Optimization conditions were examined for …
Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic …
The current work presents the synthesis and biological evaluation of new series of coumarin
hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities …
hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities …