The explosive growth in medical devices, imaging and diagnostics, computing, and
communication and information technologies in drug development and healthcare has …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

In this tutorial, the various components of NONMEM will be described, and the basic steps of
setting up NONMEM control stream files and data files will be demonstrated. Some basic …

While tumor dynamic modeling has been widely applied to support the development of
oncology drugs, there remains a need to increase predictivity, enable personalized therapy …

Longitudinal analyses of patient response time courses following doses of therapeutics are
currently performed using pharmacokinetic/pharmacodynamic (PK/PD) methodologies …

Context Copeptin is the C-terminal fragment of the arginine vasopressin (AVP) prohormone
whose measurement is more robust than that of AVP. Similar release and clearance …

Simple Summary Treatment with chimeric antigen receptor (CAR)-T cells has improved the
prognosis of patients with non-Hodgkin lymphoma (NHL) substantially. Yet, as up to 60% of …

Population pharmacokinetic (popPK) approaches have spread widely throughout clinical
pharmacology research, and every clinician should have some understanding of them. After …

Excretion of crystalloid fluid is slow during general anesthesia. The distribution and
elimination of buffered Ringer's solution were analyzed to determine whether the rate of …

Although regulatory agencies encourage inclusion of imaging biomarkers in clinical trials for
Duchenne muscular dystrophy (DMD), industry receives minimal guidance on how to use …