Metabolomics generates a profile of small molecules that are derived from cellular
metabolism and can directly reflect the outcome of complex networks of biochemical …

Summary S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-
carbon metabolism to methylation status. However, it is unknown whether regulation of SAM …

Metabolome analyses are a suite of analytical approaches that enable us to capture
changes in the metabolome (small molecular weight components, typically less than 1500 …

Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical
challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they …

Despite recent advances, many cancers remain refractory to available immunotherapeutic
strategies. Emerging evidence indicates that the tolerization of local dendritic cells (DCs) …

Targeted cancer therapies that use genetics are successful, but principles for selectively
targeting tumor metabolism that is also dependent on the environment remain unknown. We …

Summary Lysine 2-hydroxyisobutyrylation (Khib) is an evolutionarily conserved and
widespread histone mark like lysine acetylation (Kac). Here we report that p300 functions as …

Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase
isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear …

Background Glucose metabolism links metabolic status to protein acetylation. However, it
remains poorly understood to what extent do features of glucose metabolism contribute to …

Mitochondrial acyl-coenzyme A species are emerging as important sources of protein
modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial …