Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - researchgate.net
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[HTML][HTML] Syzygium cumini (L.) Skeels essential oil and its major constituent α-pinene exhibit anti-Leishmania activity through immunomodulation in vitro

KA da Franca Rodrigues, LV Amorim, CN Dias… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Syzygium cumini (L.) Skeels (Myrtaceae), commonly
known as “jambolão” in Brazil is widely used in folk medicine against leishmaniasis …

Insecticidal toxicities of carvacrol and thymol derived from Thymus vulgaris Lin. against Pochazia shantungensis Chou & Lu., newly recorded pest

JH Park, YJ Jeon, CH Lee, N Chung, HS Lee - Scientific reports, 2017 - nature.com
The insecticidal toxicities of five essential oils against Pochazia shantungensis adults and
nymphs, newly recorded pests, were evaluated. The LC50 values of Thymus vulgaris, Ruta …

[HTML][HTML] Plant-derived compounds in treatment of leishmaniasis

A Oryan - Iranian journal of veterinary research, 2015 - ncbi.nlm.nih.gov
Leishmaniasis is a neglected public health problem caused by the protozoan species
belonging to the genus Leishmania affecting mostly the poor populations of developing …

Leishmania treatment and prevention: Natural and synthesized drugs

AA Bekhit, E El-Agroudy, A Helmy, TM Ibrahim… - European journal of …, 2018 - Elsevier
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

Thymol and eugenol derivatives as potential antileishmanial agents

SM de Morais, NS Vila-Nova, CML Bevilaqua… - Bioorganic & medicinal …, 2014 - Elsevier
Abstract In Northeastern Brazil visceral leishmaniasis is endemic with lethal cases among
humans and dogs. Treatment is toxic and 5–10% of humans die despite treatment. The aim …

Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition

MA Andrade, CS Azevedo, FN Motta, ML Santos… - … and alternative medicine, 2016 - Springer
Background The current chemotherapy for cutaneous leishmaniosis (CL) has a series of
drug limitations such as toxic side effects, long duration, high costs and drug resistance …

Eugenia uniflora L. Essential Oil as a Potential Anti‐Leishmania Agent: Effects on Leishmania amazonensis and Possible Mechanisms of Action

KAF Rodrigues, LV Amorim… - Evidence‐Based …, 2013 - Wiley Online Library
Eugenia uniflora L. is a member of the Myrtaceae family and is commonly known as
Brazilian cherry tree. In this study, we evaluated the chemical composition of Eugenia …

Trypanocidal and cytotoxic activities of essential oils from medicinal plants of Northeast of Brazil

AR Borges, JR de Albuquerque Aires… - Experimental …, 2012 - Elsevier
Chagas disease, caused by Trypanosoma cruzi, is an important cause of mortality and
morbidity in Latin America. There are no vaccines available, the chemotherapy used to treat …