Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Previous studies implicated protein arginine methyltransferase 5 (PRMT5) as a synthetic
lethal target for MTAP-deleted (MTAP del) cancers; however, the pharmacologic …

While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-
length isoform changes may better elucidate the functional consequences of these …

The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-
dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is co-deleted with …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Post-translational modification (PTM) of proteins is vital for increasing proteome diversity
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …

Immunotherapies are yielding effective treatments for several previously untreatable
cancers. Still, the identification of suitable antigens specific to the tumour that can be targets …