Epidemiological studies support the notion that arterial stiffness is an independent predictor
of adverse cardiovascular events contributing significantly to systolic hypertension, impaired …

Aldosterone exerts its best known sodium homeostasis actions by controlling sodium
excretion at the level of the distal tubules via activation of the apical epithelial sodium …

Women are especially predisposed to development of arterial stiffening secondary to obesity
because of consumption of excessive calories. Enhanced activation of vascular …

Purpose: To evaluate the effect of spironolactone, a mineralocorticoid receptor antagonist,
for nonresolving central serous chorioretinopathy. Methods: This is a prospective …

Mineralocorticoid receptors (MRs) contribute to the pathophysiology of hypertension and
cardiovascular disease in humans. As such, MR antagonists improve cardiovascular …

The steroid hormone aldosterone (aldo) contributes to cardiovascular disease in animal
models and in humans. Aldo activates the mineralocorticoid receptor (MR), a hormone …

Aldosterone contributes to end-organ damage in heart failure and chronic kidney disease.
Mineralocorticoid-receptor inhibitors limit activation of the receptor by aldosterone and slow …

The renin angiotensin aldosterone system is a key regulator of blood pressure. Aldosterone
is the final effector of this pathway, acting predominantly via mineralocorticoid receptors …

Aldosterone is the most known mineralocorticoid hormone synthesized by the adrenal
cortex. The genomic pathway displayed by aldosterone is attributed to the mineralocorticoid …

Cardiovascular diseases (CVD) continue to represent the major cause of death, morbidity
and healthcare expenditure worldwide. Current medical therapy fails to effectively halt …