The role of histone methyltransferases in neurocognitive disorders associated with brain size abnormalities
FD Ritchie, SB Lizarraga - Frontiers in Neuroscience, 2023 - frontiersin.org
Brain size is controlled by several factors during neuronal development, including neural
progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis …
progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis …
A–Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer
Simple Summary Alternative splicing is a pivotal regulatory mechanism in gene expression,
generating multiple RNA species and influencing protein isoform diversity and function, as …
generating multiple RNA species and influencing protein isoform diversity and function, as …
Ash1l loss-of-function results in structural birth defects and altered cortical development
KP Toolan, BT McGrath, ML Brinkmeier, SA Camper… - Brain, 2025 - academic.oup.com
The histone methyltransferase ASH1L plays a crucial role in regulating gene expression
across various organ systems during development, yet its role in brain development remains …
across various organ systems during development, yet its role in brain development remains …
Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder
CS Leung, SJ Rosenzweig, B Yoon… - Human Molecular …, 2023 - academic.oup.com
Autism spectrum disorder (ASD) affects 1 in 44 children. Chromatin regulatory proteins are
overrepresented among genes that contain high risk variants in ASD. Disruption of the …
overrepresented among genes that contain high risk variants in ASD. Disruption of the …
Neuroimmune mechanisms in autism etiology-untangling a complex problem using human cellular models
JM Vacharasin, JA Ward, MM McCord… - Oxford Open …, 2024 - academic.oup.com
Autism spectrum disorder (ASD) affects 1 in 36 people and is more often diagnosed in males
than in females. Core features of ASD are impaired social interactions, repetitive behaviors …
than in females. Core features of ASD are impaired social interactions, repetitive behaviors …
Ash1L ameliorates psoriasis via limiting neuronal activity‐dependent release of miR‐let‐7b
WJ Du, H Yang, F Tong, S Liu, C Zhang… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Psoriasis is a common autoimmune skin disease that significantly
diminishes patients' quality of life. Interactions between primary afferents of the …
diminishes patients' quality of life. Interactions between primary afferents of the …
[HTML][HTML] Epigenetic switch controls social actions
G Pedini, C Bagni - Neuron, 2022 - cell.com
Mutations in epigenetic factors are associated with autism spectrum disorder (ASD). In this
issue of Neuron, Yan et al.(2022) show that the antagonism of ASH1L and PRC2 switches …
issue of Neuron, Yan et al.(2022) show that the antagonism of ASH1L and PRC2 switches …
Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function
Precise regulation of the chromatin environment through post-translational histone
modification modulates transcription and controls brain development. Not surprisingly …
modification modulates transcription and controls brain development. Not surprisingly …
Epigenetic Mechanisms of Autism Spectrum Disorders
Z Yan - Handbook of the Biology and Pathology of Mental …, 2024 - Springer
Genetic sequencing has identified chromatin remodelers and histone modifiers as the most
prominent risk genes for autism spectrum disorders (ASD), such as ADNP, POGZ, CHD2 …
prominent risk genes for autism spectrum disorders (ASD), such as ADNP, POGZ, CHD2 …
Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders
CS Leung, S Rosenzweig, B Yoon, NA Marinelli… - bioRxiv, 2022 - biorxiv.org
Autism spectrum disorder (ASD) affects 1 in 44 children. Chromatin regulatory proteins are
overrepresented among genes that contain high risk variants in ASD. Disruption of the …
overrepresented among genes that contain high risk variants in ASD. Disruption of the …