Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma
N Sperb, M Tsesmelis, T Wirth - International journal of molecular …, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis
calls for a more detailed understanding of disease biology in order to pave the way for the …
calls for a more detailed understanding of disease biology in order to pave the way for the …
Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy and
new therapeutics are much needed. Profiling patient leukemia drug sensitivities ex vivo, we …
new therapeutics are much needed. Profiling patient leukemia drug sensitivities ex vivo, we …
Comparison of acalabrutinib, a selective Bruton tyrosine kinase inhibitor, with ibrutinib in chronic lymphocytic leukemia cells
V Patel, K Balakrishnan, E Bibikova, M Ayres… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Ibrutinib inhibits Bruton tyrosine kinase (BTK) by irreversibly binding to the
Cys-481 residue in the enzyme. However, ibrutinib also inhibits several other enzymes that …
Cys-481 residue in the enzyme. However, ibrutinib also inhibits several other enzymes that …
CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s
Group 2 innate lymphoid cells (ILC2s) are critical for the immune response against parasite
infection and tissue homeostasis and involved in the pathogenesis of allergy and …
infection and tissue homeostasis and involved in the pathogenesis of allergy and …
Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function
VME Dunlock, AB Arp, SP Singh, S Charrin, V Nguyen… - Cell reports, 2022 - cell.com
T cells depend on the phosphatase CD45 to initiate T cell receptor signaling. Although the
critical role of CD45 in T cells is established, the mechanisms controlling function and …
critical role of CD45 in T cells is established, the mechanisms controlling function and …
Ionic CD3− Lck interaction regulates the initiation of T-cell receptor signaling
Antigen-triggered T-cell receptor (TCR) phosphorylation is the first signaling event in T cells
to elicit adaptive immunity against invading pathogens and tumor cells. Despite its …
to elicit adaptive immunity against invading pathogens and tumor cells. Despite its …
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer
Abstract Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the
treatment of homologous recombination (HR) repair deficient tumors. The remarkable …
treatment of homologous recombination (HR) repair deficient tumors. The remarkable …
De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling
L Philipsen, AV Reddycherla, R Hartig, J Gumz… - Science …, 2017 - science.org
The enzymatic activity of the Src family tyrosine kinase p56Lck (Lck) is tightly controlled by
differential phosphorylation of two tyrosine residues, Tyr394 and Tyr505. Phosphorylation of …
differential phosphorylation of two tyrosine residues, Tyr394 and Tyr505. Phosphorylation of …
Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells
M Bermejo, MR López-Huertas, J García-Pérez… - Biochemical …, 2016 - Elsevier
Massive activation of infected CD4+ T cells during acute HIV-1 infection leads to reservoir
seeding and T-cell destruction. During T-cell activation, the antiviral effect of the innate factor …
seeding and T-cell destruction. During T-cell activation, the antiviral effect of the innate factor …
Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is frequently characterized by glucocorticoid
(GC) resistance, which is associated with inferior outcomes, thus highlighting the need for …
(GC) resistance, which is associated with inferior outcomes, thus highlighting the need for …