The biological significance of substrate inhibition: a mechanism with diverse functions

MC Reed, A Lieb, HF Nijhout - Bioessays, 2010 - Wiley Online Library
Many enzymes are inhibited by their own substrates, leading to velocity curves that rise to a
maximum and then descend as the substrate concentration increases. Substrate inhibition is …

What we have gained from ibogaine: α3β4 nicotinic acetylcholine receptor inhibitors as treatments for substance use disorders

CJ Straub, LE Rusali, KM Kremiller… - Journal of medicinal …, 2022 - ACS Publications
For decades, ibogaine─ the main psychoactive alkaloid found in Tabernanthe iboga─ has
been investigated as a possible treatment for substance use disorders (SUDs) due to its …

Potential therapeutic uses of mecamylamine and its stereoisomers

JR Nickell, VP Grinevich, KB Siripurapu… - Pharmacology …, 2013 - Elsevier
Mecamylamine (3-methylaminoisocamphane hydrochloride) is a nicotinic parasympathetic
ganglionic blocker, originally utilized as a therapeutic agent to treat hypertension …

Muscle nicotinic acetylcholine receptors may mediate trans-synaptic signaling at the mouse neuromuscular junction

X Wang, JM McIntosh, MM Rich - Journal of Neuroscience, 2018 - Soc Neuroscience
Block of neurotransmitter receptors at the neuromuscular junction (NMJ) has been shown to
trigger upregulation of the number of synaptic vesicles released (quantal content, QC), a …

Acetylcholine-induced inhibition of presynaptic calcium signals and transmitter release in the frog neuromuscular junction

E Khaziev, D Samigullin, N Zhilyakov… - Frontiers in …, 2016 - frontiersin.org
Acetylcholine (ACh), released from axonal terminals of motor neurons in neuromuscular
junctions regulates the efficacy of neurotransmission through activation of presynaptic …

Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction

S Rahman, GY López-Hernández… - CNS & Neurological …, 2008 - ingentaconnect.com
Nicotine addiction and other forms of drug addiction continue to be significant public health
problems in the United States and the rest of the world. Accumulated evidence indicates that …

Ионотропные рецепторы ацетилхолина и АТФ: механизмы ингибирования

АИ Скоринкин - Успехи физиологических наук, 2013 - elibrary.ru
В обзоре проанализированы два класса рецепторов, сопряженных с ионными
каналами. Первые-это рецепторы, открытие ионных каналов которых вызывается …

[引用][C] Lumbriculus variegatus: Investigating a Novel in vivo Model for Substances of Abuse

R Mahmood - 2024